Assessment of Cardiavascular Changes following Trans-sphenoidal Surgery in Acromegalic Patients

Management of intra-operative cerebrospinal fluid leak following endoscopic trans-sphenoidal pituitary surgery.

OBJECTIVE Cerebrospinal fluid leakage is the most common complication of endoscopic trans-sphenoidal pituitary surgery. However, there is no uniformly accepted way of managing this complication when it occurs intra-operatively. This paper describes a quick, simple technique, involving layered fibrin glue and gelatin sponge, which does not compromise post-operative patient follow up. METHOD Re...

The History of Trans-sphenoidal Surgery for Pituitary Tumours

The Results of Transsphenoidal Acromegalic Patients Surgery for 44 Consecutive

A series of 44 patients with acromegaly underwent transsphenoidal surgery between 1987 and 1996. The early postoperative mean basal GH level < 5 ng/ml or < 3 ng/ml was achieved in 43 (97.7%) or 38 (86.4%) out of 44 patients, respectively. Preoperative abnormal GH secretory response to TRH, GnRH and oral glucose administration was restored to normal both after surgery and at the time of the fina...

Angio-oedema after trans-sphenoidal surgery in a patient with Cushing's disease.

Cushing’s disease is bilateral adrenocortical hyperplasia secondary to excessive secretion of ACTH by the pituitary gland. Angio-oedema is due to oedema in the deeper subcutaneous and submucosal tissues. We report a patient with acquired angio-oedema which developed after transsphenoidal surgery for Cushing’s disease (CD). A 50-year-old woman admitted to the endocrinology department with a two-...

A New Irrigation System (Endosplash) for a Rigid Endoscope in Trans-sphenoidal Endoscopic Surgery

Obstruction of the visual field by blood is a major hindrance during endonasal endoscopic surgery, and a rapid and effective method for cleaning the lens is needed. We developed a new lens-cleaning system that does not employ a sheath or an irrigation-suction system. It is a 20-mm long cylinder with side holes that is attached to the barrel of the endoscope and is connected to a syringe contain...